Personal profile
Bei GAO
Email: wintergb@hotmail.com
RESEARCH INTEREST
Environmental toxicology; Metabolomics; Lipidomics; Stable isotope tracing; Gut microbiome
PROFESSIONAL TRAINING AND EXPERIENCES
07/2023- Associate professor, Nanjing University of Information Science and Technology, Nanjing, China
10/2020-06/2023 Assistant professor, Nanjing University of Information Science and Technology, Nanjing, China
1/2019-9/2020 Postdoctoral scholar, Department of Medicine, University of California, San Diego, USA
1/2017-12/2018 Postdoctoral scholar, NIH West Coast Metabolomics Center, University of California, Davis, USA
8/2016-12/2016 Visiting Scholar, University of North Carolina at Chapel Hill, USA
EDUCATION
8/2013-12/2016 Ph.D., Environmental Health Science, University of Georgia, USA
9/2010-7/2013 M.S., Biochemistry and Molecular Biology, Shanghai Ocean University, China
9/2006-7/2010 B.S., Food Science and Engineering (Public Nutrition), Dalian Polytechnic University, China
FUNDING
1. National Natural Science Foundation of China, ¥300,000, 2022.01.01-2024.12.31, PI
2. Key Technology R&D Program of Jiangsu Province, ¥3,000,000, 2022.07-2025.06, co-PI
3. Science and Technology Innovation Project of Nanjing City, ¥30,000, 2022.07-2023.07, PI
4. Nanjing University of Information Science and Technology Startup Funding, ¥300,000, 2021.01.01-2023.12.31, PI
PROFESSIONAL SERVICE
1. Environmental Health Perspectives Editorial Review Board Member
2. Metabolites Editorial Board Member
Special Issue Guest Editor "Effects of Environmental Exposure on Host and Microbial Metabolism"
https://www.mdpi.com/journal/metabolites/special_issues/VKC5O283QF
Special Issue Guest Editor "Dietary Effects on Gut Microbial Metabolism and Intestinal Inflammation in Mammals" https://www.mdpi.com/journal/metabolites/special_issues/dietary_gut_microbial_metabolism_mammal
3. Frontiers in Nutrition Review Editor
Special Issue Guest Associate Editor“Edible Mushrooms and the Gut Microbiota”
https://www.frontiersin.org/research-topics/45450/edible-mushrooms-and-the-gut-microbiota
PEER-REVIEWED PUBLICATIONS
Gao B, Shi X, Li S, Xu W, Gao N, Shan J, Shen W. Size-dependent effects of polystyrene microplastics on gut metagenome and antibiotic resistance in C57BL/6 mice. Ecotoxicology and Environmental Safety,2023,254,114737. doi: 10.1016/j.ecoenv.2023.114737.
Tu P, Tang Q, Mo Z, Niu H, Hu Y, Wu L, Chen Z, Wang X*, Gao B*( Co-corresponding author). Dietary administration of black raspberries and arsenic exposure:changes in the gut microbiota and its functional metabolites. Metabolites, 2023, 13(2), 207; doi:10.3390/metabo13020207.
Martino C#, Zaramela L#, Gao B# (Co-first author), Embree M, Tarasova1 J, Parker S, Wang Y, Chu H,Chen P, Lee K, Galzeranil D, Gengatharan J, Lekbua A, Neal M, Knight R, Tuskamoto H, Metallo C, Schnabl B, Zengler K. Acetate reprograms gut microbiota during alcohol consumption.Nature Communications,2022, 13. 4630. doi:10.1038/s41467-022-31973-2.
Gao B, Tu P, Chi L, Shen W, Gao N. Perfluorooctanoic acid-disturbed serum and liver lipidome in C57BL/6 mice. Chemical Research in Toxicology.2022,12. doi:10.1021/acs.chemrestox.2c00239.
Gao B, Zhu Y ,Shen W ,Stärkel P ,Schnabl B. Correlation between serum steroid hormones and gut microbiota in patients with alcohol-associated liver disease.Metabolites, 2022; 12(11):1107. doi:10.3390/metabo12111107.
Shi X#, Gao B#(Co-first author),Srivastava A,Izzi Z,Abdalla Y,Shen W, Raj D. Alterations of gut microbial pathways and virulence factors in hemodialysis patients. Frontiers in Cellular and Infection Microbiology, 2022, doi:10.3389/fcimb.2022.904284.
Gao B, Zeng S, Maccioni L, Shi X, Armando A, Quehenberger O, Zhang X, Starkel P, Schnabl B. Lipidomics for the Prediction of Progressive Liver Disease in Patients with Alcohol Use Disorder. Metabolites, 2022,12, (5); doi: 10.3390/metabo12050433.Selected as Particular Interest Paper.
Gao B#, Wu T# (Co-first author), Lang S, Lu J, Duan Y, Fouts D, Zhang X, Tu X, Schnabl B. Random forest applied to omics datasets accurately predicts mortality in patients with alcoholic hepatitis. Metabolites. Metabolites 2022, 12(1), 41; doi:10.3390/metabo12010041.
Gao B, Jose A, Alonzo-Palma N, Malik T, Shakaranaryanan D, Regunathan-Shenk R, Raj D. Butyrate Producing Microbiota are Reduced in Chronic Kidney Diseases. Scientific Reports, 11, 23530 (2021), doi:10.1038/s41598-021-02865-0.
Gao B, Zhu Y, Gao N, Shen W, Starkel P, Schnabl. Integrative analysis of metabolome and microbiome in patients with progressive liver disease. Metabolites 2021, 11, 766. https://doi.org/10.3390/ metabo11110766.
Gao B, Chi L, Zhu Y, Shi X, Tu P,Li B, Yin J, Gao N, Shen W, Schnabl B. An Introduction to Next Generation Sequencing Bioinformatic Analysis in Gut Microbiome Studies. Biomolecules.2021. doi: 10.3390/biom11040530.
Gao B, Emami A, Nath S, Schnabl B. Microbial products and metabolites contributing to alcohol-related liver disease. Mol. Nutr. Food Res. 2021 Mar;65(5):e2000023; doi: 10.1002/mnfr.202000023.
Gao B, Argemi J, Bataller R, Schnabl. Serum acylcarnitines associated with high short-term mortality in patients with alcoholic hepatitis. Biomolecules.2021 Feb 14;11(2):281; doi:10.3390/biom11020281.
Gao B, Friedman E, Regunathan R, Shrivastava A, Barrows I, Amdur R, Andrews S, Barrows E, Raj D. Gut Microbiota and Host Cometabolism Are Altered by Patiromer-Induced Changes in Serum and Stool Potassium. Kidney International reports. 2021 Mar; 6(3): 821–829; doi: 10.1016/j.ekir.2020.12.026.
Gao B#, Zhang X# (Co-first author), Schnabl B. Fungi-bacteria Correlation in Alcoholic Hepatitis Patients. Toxins. 2021 Feb 14;13(2):143; doi:10.3390/toxins13020143.
Lang S#, Fairfied B#, Gao B# (Co-first author), Duan Y, Zhang X, Fouts D, Schnabl B. Changes in the fecal bacterial microbiota associated with disease severity in alcoholic hepatitis patients. Gut Microbes. 2020 Nov 9;12(1):1785251; doi:10.1080/19490976.2020.1785251.
Gao B#, Duan Y# (Co-first author), Lang S, Barrupal D, Wu T, Valdiviez L, Roberts B, Choy Y, Shen T, Byram G, Zhang Y, Fan S, Wancewicz B, Shao Y, Vervier K, Wang Y, Zhou R, Jiang L, Nath S, Looma R, Abraldes J, Bataller R, Tu X, Starkel P, Lawley T, Fiehn O, Schnabl B. Functional microbiomics reveals alterations of the gut microbiome and host co-metabolism in alcoholic hepatitis patients. Hepatol. Commun. 2020 Jun 19;4(8):1168-1182; doi:10.1002/hep4.1537.
Gao B, Alonzo-Palma N, Brooks B, Jose A, Barupal D, Jagadeesan M, Nobakht, E, Collins A, Ramezani A, Omar B, Amdur R, Raj D. A Pilot Study On the Effect of Prebiotic on Host-Microbial Co-metabolism in Peritoneal Dialysis Patients. Kidney International reports. 2020 Jun 1;5(8):1309-1315.; doi:10.1016/j.ekir.2020.05.023.
Gao B, Emami A, Zhou R, Lang S, Duan Y, Wang Y, Lu J, Loomba R, Brenner D, Starkel P, Schnabl B. Functional microbial responses to alcohol abstinence in patients with alcohol use disorder. Front. Physiol. 2020 Apr 24;11:370; doi: 10.3389/fphys.2020.00370.
Gao B, Chi L, Tu P, Gao N, Lu K. The Carbamate Aldicarb Altered the Gut Microbiome, Metabolome, and Lipidome of C57BL/6J Mice. Chem Res Toxicol. 2019 Jan 22;32(1):67-79. doi: 10.1021/acs.chemrestox.8b00179.
Gao B, Lue HW, Podolak J, Fan S, Zhang Y, Serawat A, Alumkal JJ, Fiehn O, Thomas GV. Multi-Omics Analyses Detail Metabolic Reprogramming in Lipids, Carnitines, and Use of Glycolytic Intermediates between Prostate Small Cell Neuroendocrine Carcinoma and Prostate Adenocarcinoma. Metabolites. 2019 Apr 26;9(5). doi: 10.3390/metabo9050082. Selected as Journal Issue Cover.
Gao B, Lang S, Duan Y, Wang Y, Shawcross DL, Louvet A, Mathurin P, Ho SB, Stärkel P, Schnabl B. Serum and Fecal Oxylipins in Patients with Alcohol-Related Liver Disease. Dig Dis Sci. 2019 Jul;64(7):1878-1892. doi: 10.1007/s10620-019-05638-y.
16. Barupal DK#, Gao B# (Co-first author), Budczies J, Phinney BS, Perroud B, Denkert C, Fiehn O. Prioritization of metabolic genes as novel therapeutic targets in estrogen-receptor negative breast tumors using multi-omics data and text mining. Oncotarget. 2019 Jun 11;10(39):3894-3909. doi: 10.18632/oncotarget.26995.
Gao B#, Gallagher T# (Co-first author), Zhang Y, Elbadawi-Sidhu M, Lai Z, Fiehn O, Whiteson KL. Tracking Polymicrobial Metabolism in Cystic Fibrosis Airways: Pseudomonas aeruginosa Metabolism and Physiology Are Influenced by Rothia mucilaginosa-Derived Metabolites. mSphere. 2018 Apr 25;3(2). doi: 10.1128/mSphere.00151-18.
Gao B, Chi L, Tu P, Bian X, Thomas J, Ru H, Lu K. The organophosphate malathion disturbs gut microbiome development and the quorum-Sensing system. Toxicol Lett. 2018 Feb;283:52-57. doi: 10.1016/j.toxlet.2017.10.023.
Gao B, Bian X, Chi L, Tu P, Ru H, Lu K. Editor's Highlight: Organophosphate Diazinon Altered Quorum Sensing, Cell Motility, Stress Response, and Carbohydrate Metabolism of Gut Microbiome. Toxicol Sci. 2017 Jun 1;157(2):354-364. doi: 10.1093/toxsci/kfx053. Selected as Editor’s Highlight.
Gao B, Chi L, Mahbub R, Bian X, Tu P, Ru H, Lu K. Multi-Omics Reveals that Lead Exposure Disturbs Gut Microbiome Development, Key Metabolites, and Metabolic Pathways. Chem Res Toxicol. 2017 Apr 17;30(4):996-1005. doi: 10.1021/acs.chemrestox.6b00401.
Gao B#, Tu P# (Co-first author), Bian X, Chi L, Ru H, Lu K. Profound perturbation induced by triclosan exposure in mouse gut microbiome: a less resilient microbial community with elevated antibiotic and metal resistomes. BMC Pharmacol Toxicol. 2017 Jun 12;18(1):46. doi: 10.1186/s40360-017-0150-9. Selected as BMC Pharmacology and Toxicology 2017 Highlight.
Gao B, Bian X, Mahbub R, Lu K. Sex-Specific Effects of Organophosphate Diazinon on the Gut Microbiome and Its Metabolic Functions. Environ Health Perspect. 2017 Feb;125(2):198-206. doi: 10.1289/EHP202. Selected as Papers of the Month by the NIEHS.
Duan Y, Llorente C, Lang S, Brandl K, Chu H, Jiang L, White R, Clarke T, Nguyen K, Torralba M, Shao Y, Liu J, Hernandez-Morales A, Lessor L, Rahman I, Miyamoto Y, Ly M, Gao B, Sun W, Kiesel R, Hutmacher F, Lee S, Ventura-Cots M, Bosques-Padilla F, Verna E, Abraldes J, Brown Jr R, Vargas V, Altamirano J, Caballería J, Shawcross D, Ho S, Louvet A, Lucey M, Mathurin P, Garcia-Tsao G, Bataller R, Tu X, Eckmann L, Donk W, Young R, Lawley T, Stärkel P, Pride D, Fouts D, Schnabl B. Bacteriophage targeting of gut bacterium attenuates alcoholic liver disease. Nature. 2019 Nov;575(7783):505-511; doi:10.1038/s41586-019-1742-x. Comment in Microbial clues to a liver disease by Clokie MRJ; Manipulating the gut microbiota to combat alcoholic hepatitis by Ray K; Phages fight alcoholic hepatitis by Crunkhorn S; Bacteriophage prevents alcoholic liver disease by Colakoglu M Xue J and Trajkovski M.
Cai D, Wang J, Gao B, Li J, Wu F, Zou J, Xu J, Jiang Y, Zou H, Huang Z, Borowsky A, Bold R, Lara P, Li J, Chen X, Lam K, To K, Kung H, Fiehn O, Zhao R, Evans R, Chen H. RORγ is a targetable master regulator of cholesterol biosynthesis in a cancer subtype. Nat. Commun. 2019; 10:4621. doi: 10.1038/s41467-019-12529-3.
Jiang L, Lang S, Duan Y, Zhang X, Gao B, Chopyk J, Schwanemann L, Ventura-Cots M, Bataller R, Bosques-Padilla F, Verna E, Abraldes J, Brown R, Vargas V, Altamirano J, Caballeria J, Shawcross D, Ho S, Louvet A, Lucey M, Mathurin P, Garcia-Tsao G, Kisseleva T, Brenner D, Tu X, Starkel P, Pride S, Pride D, Fouts D, Schnabl B. Intestinal virome in patients with alcoholic hepatitis. Hepatology. 2020, July 12; doi:10.1002/hep.31459.IF 14.971
Lang S, D Münevver, Martin A, Jiang L, Zhang X, Duan Y, Gao B, Wisplinghoff H, Kasper P, Roderburg C, Tacke F, Steffen H, Goeser T, Abraldes J, Tu X, Loomba R, Pride D, Fouts D, Schnabl B. Intestinal Virome Signature Associated With Severity of Nonalcoholic Fatty Liver Disease. Gastroenterology. 2020; doi: 10.1053/j.gastro.2020.07.005.
Hendrikx T, Duan Y, Wang Y, Oh JH, Alexander LM, Huang W, Stärkel P, Ho SB, Gao B, Fiehn O, Emond P, Sokol H, van Pijkeren JP, Schnabl B. Bacteria engineered to produce IL-22 in intestine induce expression of REG3G to reduce ethanol-induced liver disease in mice. Gut. 2019 Aug;68(8):1504-1515. doi: 10.1136/gutjnl-2018-317232.
Kouno T, Zeng S,Wang Y, Duan Y, Lang S, Gao B,Hartmann P, Cabre N, Llorente C,Galbert C, Emond P, Sokol H,James M, Chao C, Gao J, Perreault M, Hava D, B Schnabl. Engineered bacteria producing aryl-hydrocarbon receptor agonists protect against ethanol-induced liver disease in mice. Alcoholism: Clinical and Experimental Research. Alcohol Clin Exp Res. 2023 Mar 5. doi: 10.1111/acer.15048.
Wang Y, Liu Y, Gao B, Yan J, Cai W, Jiang L. Untargeted metabolomics reveal parenteral nutrition-associated alterations in pediatric patients with short bowel syndrome.Metabolites.2022 Jun 27;12(7):600. doi: 10.3390/metabo12070600
Tu P, Chi L,Bian X,Gao B,Ru H,Lu K. A black raspberry-rich diet protects from dextran sulfate sodium-induced intestinal inflammation and host metabolic dysbiosis in association with increased aryl hydrocarbon receptor ligands in the gut microbiota of mice. Frontiers in Nutrition. 2022 Jun, doi:10.3389/fnut.2022.842298
Liu M,Jiang J, Zheng J, Huan T, Gao B, Fei X,Wang Y, Fang M. RTP: One Effective Platform to Probe Reactive Compound Transformation Products and Its Applications for a Reactive Plasticizer BADGE. Environmental Science & Technology.2021 Dec 7;55(23):16034-16043.doi:10.1021/acs.est.1c05262.
Zhou R, Llorente C, Cao J, Zaramela LS, Zeng S, Gao B, Li S-Z, Welch RD, Huang F-Q, Qi L-W, Pan C, Huang Y, Zhou P, Beussen I, Zhang Y, Bryam G, Fiehn O, Wang L, Liu E- H, Yu RT, Downes M, Evans RM, Goglin K, Fouts DE, Brenner DA, Bode L, Fan X, Zengler K, Schnabl B. Intestinal α1-2-fucosylation contributes to obesity and steatohepatitis in mice. Cellular and Molecular Gastroenterology and Hepatology (2021), doi: 10.1016/j.jcmgh.2021.02.009.
Beaudry M, Wang J, Kieran T, Thomas J, Bayona-Vasquez N, Gao B, Devault A, Brunelle B,Lu K,Wang J, Rhodes O, Glenn T. Improved microbial community characterization of 16S rRNA via metagenome hybridization capture enrichment. Front. Microbiol., 2021 April;doi:10.3389/fmicb.2021.644662.
Zhang Y, Gao B, Valdiviez L, Zhu C, Gallagher T, Whiteson K, Fiehn O. Comparing Stable Isotope Enrichment by Gas Chromatography with Time-of-Flight, Quadrupole Time-of-Flight, and Quadrupole Mass Spectrometry. Analytical Chemistry.2021, Jan 12; doi: 10.1021/acs.analchem.0c04013.
Zhou R, Llorente C, Cao J, Gao B, Duan Y, Jiang L, Wang Y, Vipin K, Peter S, Lars B, Fan X, Schnabl B. Deficiency of intestinal α1-2-fucosylation exacerbates ethanol-induced liver disease in mice. Alcoholism: Clinical and Experimental Research. 2020, July 6; doi: 10.1111/acer.14405.
Maccioni L, Gao B, Leclercq S, Pirlot B, Horsmans Y, Timary P, Leclercq I, Fouts D, Schnabl B, Stärkel P. Intestinal permeability, microbial translocation, changes in duodenal and fecal microbiota, and their associations with alcoholic liver disease progression in humans. Gut Microbes. 2020, June 26; doi: 10.1080/19490976.2020.1782157.
Jiang L, Chu H, Gao B, Lang S, Wang Y, Duan Y, Schnabl B. Transcriptomic profiling identifies novel hepatic and intestinal genes following chronic plus binge ethanol feeding in mice. Dig Dis Sci. 2020. doi: 10.1007/s10620-020-06461-6.
Chu H, Jiang L, Gao B, Gautam N, Alamoudi J, Lang S, Wang Y, Duan Y, Alnouti Y, Cable E, Schnabl B. The selective PPAR-delta agonist seladelpar reduces ethanol-induced liver disease by restoring gut barrier function and bile acid homeostasis in mice. Transl Res. 2020; doi:10.1016/j.trsl.2020.06.006.
Tu P, Chi L, Bodnar W, Zhang Z, Gao B, Bian X, Stewart J, Fry R, Lu K. Gut Microbiome Toxicity: Connecting the Environment and Gut Microbiome-associated Diseases. Toxics 2020, 8(1), 19; doi:10.3390/toxics8010019. Selected as Journal Issue Cover.
Tu P, Bian X, Chi L, Xue J, Gao B, Lai Y, Ru H, Lu K. Metabolite profiling of the gut microbiome in mice with dietary administration of black raspberries. ACS Omega. 2020; doi:10.1021/acsomega.9b00237.
Glenn T, Pierson T, Bayona-Vásquez N, Kieran T, Hoffberg S, Thomas J, Lefever D, Finger J, Gao B, Bian X, Louha S, Kohli R, Bentley K, Rushmore J, Wong K, Shaw T, Rothrock M, Mckee A, Guo T, Mauricio R, Molina M, Cummings B, Lash L, Lu K, Gilbert G, Hubbell S, Faircloth B. Adapterama II: Universal amplicon sequencing on illumina platforms (TaggiMatrix). PeerJ. 2019; 7:e7786. doi:10.7717/peerj.7786.
Xia Y, Ye B, Ding J, Yu Y, Alptekin A, Thangaraju M, Prasad PD, Ding ZC, Park EJ, Choi JH, Gao B, Fiehn O, Yan C, Dong Z, Zha Y, Ding HF. Metabolic Reprogramming by MYCN Confers Dependence on the Serine-Glycine-One-Carbon Biosynthetic Pathway. Cancer Res. 2019 Aug 1;79(15):3837-3850. doi: 10.1158/0008-5472.CAN-18-3541.
Tu P, Xue J, Bian X, Chi L, Gao B, Leng J, Ru H, Knobloch TJ, Weghorst CM, Lu K. Dietary administration of black raspberries modulates arsenic biotransformation and reduces urinary 8-oxo-2'-deoxyguanosine in mice. Toxicol Appl Pharmacol. 2019 Aug 15;377:114633. doi: 10.1016/j.taap.2019.114633.
Tu P, Gao B, Chi L, Lai Y, Bian X, Ru H, Lu K. Subchronic low-dose 2,4-D exposure changed plasma acylcarnitine levels and induced gut microbiome perturbations in mice. Sci Rep. 2019 Mar 13;9(1):4363. doi: 10.1038/s41598-019-40776-3.
Lai Y, Xue J, Liu CW, Gao B, Chi L, Tu P, Lu K, Ru H. Serum Metabolomics Identifies Altered Bioenergetics, Signaling Cascades in Parallel with Exposome Markers in Crohn's Disease. Molecules. 2019 Jan 27;24(3). doi: 10.3390/molecules24030449.
Tu P, Bian X, Chi L, Gao B, Ru H, Knobloch TJ, Weghorst CM, Lu K. Characterization of the Functional Changes in Mouse Gut Microbiome Associated with Increased Akkermansia muciniphila Population Modulated by Dietary Black Raspberries. ACS Omega. 2018 Sep 30;3(9):10927-10937. doi: 10.1021/acsomega.8b00064.
Nusbaum DJ, Sun F, Ren J, Zhu Z, Ramsy N, Pervolarakis N, Kunde S, England W, Gao B, Fiehn O, Michail S, Whiteson K. Gut microbial and metabolomic profiles after fecal microbiota transplantation in pediatric ulcerative colitis patients. FEMS Microbiol Ecol. 2018 Sep 1;94(9). doi: 10.1093/femsec/fiy133. Selected as Editor’s Choice.
Shan J, Peng L, Qian W, Xie T, Kang A, Gao B, Di L. Integrated Serum and Fecal Metabolomics Study of Collagen-Induced Arthritis Rats and the Therapeutic Effects of the Zushima Tablet. Front Pharmacol. 2018, Aug 14;9:891. doi: 10.3389/fphar.2018.00891.
Chi L, Gao B, Tu P, Liu CW, Xue J, Lai Y, Ru H, Lu K. Individual susceptibility to arsenic-induced diseases: the role of host genetics, nutritional status, and the gut microbiome. Mamm Genome. 2018 Feb;29(1-2):63-79. doi: 10.1007/s00335-018-9736-9.
Chi L, Bian X, Gao B, Tu P, Lai Y, Ru H, Lu K. Effects of the Artificial Sweetener Neotame on the Gut Microbiome and Fecal Metabolites in Mice. Molecules. 2018 Feb 9;23(2). doi: 10.3390/molecules23020367.
Chi L, Mahbub R, Gao B, Bian X, Tu P, Ru H, Lu K. Nicotine Alters the Gut Microbiome and Metabolites of Gut-Brain Interactions in a Sex-Specific Manner. Chem Res Toxicol. 2017 Dec 18;30(12):2110-2119. doi: 10.1021/acs.chemrestox.7b00162. Featured by the American Chemical Society press release. Recommended in F1000Prime.
Chi L, Bian X, Gao B, Tu P, Ru H, Lu K. The Effects of an Environmentally Relevant Level of Arsenic on the Gut Microbiome and Its Functional Metagenome. Toxicol Sci. 2017 Dec 1;160(2):193-204. doi: 10.1093/toxsci/kfx174.
Chi L, Gao B, Bian X, Tu P, Ru H, Lu K. Manganese-induced sex-specific gut microbiome perturbations in C57BL/6 mice. Toxicol Appl Pharmacol. 2017 Sep 15;331:142-153. doi: 10.1016/j.taap.2017.06.008.
Bian X, Tu P, Chi L, Gao B, Ru H, Lu K. Saccharin induced liver inflammation in mice by altering the gut microbiota and its metabolic functions. Food Chem Toxicol. 2017 Sep;107(Pt B):530-539. doi: 10.1016/j.fct.2017.04.045.
Bian X, Chi L, Gao B, Tu P, Ru H, Lu K. Gut Microbiome Response to Sucralose and Its Potential Role in Inducing Liver Inflammation in Mice. Front Physiol. 2017;8:487. doi: 10.3389/fphys.2017.00487.
Bian X, Chi L, Gao B, Tu P, Ru H, Lu K. The artificial sweetener acesulfame potassium affects the gut microbiome and body weight gain in CD-1 mice. PLoS One. 2017;12(6):e0178426. doi: 10.1371/journal.pone.0178426.
Chi L, Bian X, Gao B, Ru H, Tu P, Lu K. Sex-Specific Effects of Arsenic Exposure on the Trajectory and Function of the Gut Microbiome. Chem Res Toxicol. 2016 Jun 20;29(6):949-51. doi: 10.1021/acs.chemrestox.6b00066.
Educational Experience
Work Experience
Research Focus
主要研究方向为海洋污染物的健康风险评估;代谢组学;脂质组学;稳定性同位素示踪;肠道微生物;大数据挖掘与分析;液相色谱-质谱联用;气相色谱-质谱联用;生物信息学;化学信息学;土壤微生物生态; 微塑料