点击次数：

影响因子：5.32

DOI码：10.1007/s00330-021-08051-0

发表刊物：European Radiology

关键字：Epilepsy; Positron emission tomography; Classification; Logistic models

摘要：Objectives: Atypical benign epilepsy with centro-temporal spikes (BECTS) have less favorable outcomes than typical BECTS, and thus should be accurately identified for adequate treatment. We aimed to investigate the glucose metabolic differences between typical and atypical BECTS using 18F-fluorodeoxyglucose positron emission tomography ([18F]FDG PET) imaging, and explore whether these differences can help distinguish.
Methods: Forty-six patients with typical BECTS, 31 patients with atypical BECTS and 23 controls who underwent [18F]FDG PET examination were retrospectively involved. Absolute asymmetry index (|AI|) was applied to evaluate the severity of metabolic abnormality. Glucose metabolic differences were investigated among typical BECTS, atypical BECTS, and controls by using statistical parametric mapping (SPM). Logistic regression analyses were performed based on clinical, PET, and hybrid features.
Results: The |AI| was found significantly higher in atypical BECTS than in typical BECTS (p = 0.040). Atypical BECTS showed more hypo-metabolism regions than typical BECTS, mainly located in the fronto-temporo-parietal cortex. The PET model had significantly higher area under the curve (AUC) than the clinical model (0.91 vs. 0.70, p = 0.006). The hybrid model had the highest sensitivity (0.90), specificity (0.85), and accuracy (0.87) of all three models.
Conclusions: Atypical BECTS showed more widespread and severe hypo-metabolism than typical BECTS, depending on which the two groups can be well distinguished. The combination of metabolic characteristics and clinical variables has the potential to be used clinically to distinguish between typical and atypical BECTS.

论文类型：期刊论文

学科门类：医学

文献类型：J

卷号：31

页面范围：9335-9345

是否译文：否

发表时间：2021-05-29

收录刊物：SCI

发布刊物链接：https://link.springer.com/article/10.1007/s00330-021-08051-0